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Paroxetine-amitriptyline

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| to = amitriptyline  
| to = amitriptyline  
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| stop =  
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* '''Before day 1:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
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{{stopParoxetine}}
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* '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day.
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* '''Day 8:''' stop administration of paroxetine
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| start =  
| start =  
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* '''Day 8:''' start administration of amitriptyline in a low dosage of 25-50 mg/day.  
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* '''Day 9:''' start administration of amitriptyline in a low dosage of 25-50 mg/day.  
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* '''Day 15:''' if necessary increase dosage of amitriptyline to a dosage of 50-100 mg/day.
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* '''Day 16:''' if necessary increase dosage of amitriptyline to a dosage of 50-100 mg/day.
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| info =  
* Paroxetine slows the metabolism of amitriptyline via CYP2D6.  
* Paroxetine slows the metabolism of amitriptyline via CYP2D6.  
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Current revision as of 13:07, 28 October 2015

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from paroxetine to amitriptyline.

Nietinrijdenbord.png Stop paroxetine
Eenrichtingbord.png Start amitriptyline
Infobord.png More information
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