Difference between revisions of "Rest AP-Olanzapine LA"

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| from = Rest AP
 
| from = Rest AP
 
| to = Olanzapine_LA
 
| to = Olanzapine_LA
| stop = {{Downslweeks}}
+
| stop = {{StopStand}}
| start = {{StartDepot}}
+
| start = {{StartDepot-no-dot}}
| info = {{caveQT}}{{Alternatief}}
+
| info = {{caveQT}}
| view = Stop10WeeksStartDepot.jpg
+
| caveat =
 +
* {{olanzapine-oral}}  
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| view =  
 
}}
 
}}

Revision as of 08:59, 11 March 2010

Rest anti-psychotics

Chlorprothixene
Flupentixol
Loxapine
Pericyazine
Perphenazine
Trifluoperazine
Ziprasidone
Zuclopenthixol

Olanzapine
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Olanzapine
EMEA zypadhera
PubChem 4585
PubMed Olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine

Switch medication from Rest AP to Olanzapine_LA.[1] [2]

Nietinrijdenbord.png Stop Rest AP
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Olanzapine_LA
  • Day 1: Start depot according general dosing advice
Letopbord.png Cave
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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