Difference between revisions of "Risperidone-Lurasidone"

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{{Drugswitch  
 
{{Drugswitch  
 
| from = Risperidone
 
| from = Risperidone
| to = Lurasidon
+
| to = Lurasidone
| stop =  
+
| stop = {{StopStand}}
* '''Day 1-7:''' gradually reduce the dose of risperidone to 50% of the dose.
+
| start = {{StartStand}}
* '''Day 8-14:''' gradually reduce the dose of risperidone to 0% of the dose
+
| info =  
* '''Day 14:''' stop administration of risperidone.
+
{{RefSwitchToLurasidone}}
| start =  
+
| view = switchstandaardup en down.jpg
* '''Day 1-7:''' start administration of lurasidon in a dose of 40 mg/day.
 
* '''Day 8-14:''' increase the dose of lurasidon to 80 mg/day if necessary. Note: Continue the dose of lurasidone 40 mg/day if the patiënt is stable. 
 
| info = {{caveQT}}
 
* It is also possible to start administration of lurasidon on day 1 in a dose of 80 mg/day. <ref>[http://www.ncbi.nlm.nih.gov/pubmed/23473350 McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.]</ref>
 
 
}}
 
}}

Latest revision as of 11:53, 22 March 2015

Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone
Lurasidone
Type Antipsychotic
Group Atypical AP
links
Medscape Lurasidone
PubMed Lurasidone
Kompas (Dutch) Lurasidone
Wikipedia Lurasidone

Switch medication from Risperidone to Lurasidone.[4] [5]

Nietinrijdenbord.png Stop Risperidone
  • Day 1-4: approx. 75% of initial dose
  • Day 5-8: approx. 50% of initial dose
  • Day 9-12: approx. 25% of initial dose
  • Day 13: stop
Eenrichtingbord.png Start Lurasidone
  • Day 1-4: approx. 25% of target dose
  • Day 5-8: approx. 50% of target dose
  • Day 9-12: approx. 75% of target dose
  • Day 13: target dose
Infobord.png More information
  • More information on switching to lurasidon: see reference. [6]
    Switchstandaardup en down.jpg
Nietinrijdenbord.png — Risperidone
Eenrichtingbord.png — Lurasidone


  1. 1.0 1.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
  2. Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  3. 3.0 3.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
  4. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  5. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  6. McEvoy JP et al. Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study.J Clin Psychiatry. 2013 Feb;74(2):170-9.
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