Sertraline-amitriptyline

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Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from sertraline to amitriptyline.

Nietinrijdenbord.png Stop sertraline
  • Day 0: gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day.
  • Day 1: reduce dosage of sertraline to a maximum of 25 mg/day.
  • Day 8: stop administration of sertraline.
Eenrichtingbord.png Start amitriptyline

Caution is necessary.

  • Day 1: simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.
  • Day 8: continue administration of amitriptyline in a dosage of 50 mg/day.
  • Start low, go slow!
Infobord.png More information
  • Sertraline dose-dependently slows the metabolism of amitriptyline via CYP2D6.
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