Sertraline-maprotiline

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Sertraline
Type Antidepressant
Group SSRI
links
Medscape Sertraline
PubChem 68617
PubMed Sertraline
Kompas (Dutch) Sertraline
Wikipedia Sertraline
Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline

Switch medication from sertraline to maprotiline.

Nietinrijdenbord.png Stop sertraline
  • Before day 1: Gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.
  • Day 1: Reduce dosage of sertraline to a dosage of 25 mg/ day
  • Day 8: Stop administration of sertraline
Eenrichtingbord.png Start maprotiline

Caution is necessary.

  • Day 1: simultaneously start administration of maprotiline in a low dosage of 25 mg/day.
  • Day 8: stop administration of sertraline and only continue administration of maprotiline in a dosage of 50 mg/day.
  • "Start low, go slow" is not required, but caution is necessary.
Infobord.png More information
  • Sertraline dose-dependently slows the metabolism of maprotiline via CYP2D6.
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