Tranylcypromine-sertraline

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• Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
• When a dosage of 10 mg/day is reached, stop administration.

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• Day 1-14: a wash-out period of two weeks is necessary.
• Day 15: start sertralin after this period in a normal dosage of 50 mg/day.

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• Occurrence of the serotonin syndrome is possible without a wash-out period.
• The wash-out period is necessary for the MAO enzymes to restore their function.

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