Difference between revisions of "Trazodone-amitriptyline"

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* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.  
 
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.  
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
+
* '''Day 1:''' reduce dosage of trazodone to 100 mg/day.
 
* '''Day 8:''' stop administration of trazodone.
 
* '''Day 8:''' stop administration of trazodone.
 
| start =  
 
| start =  

Revision as of 13:24, 20 May 2009

Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from trazodone to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop trazodone
  • Before day 0: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 100 mg/day.
  • Day 8: stop administration of trazodone.
Eenrichtingbord.png Start amitriptyline

No wash-out period is needed.

  • Day 1: simultaneously start administration of amitriptyline in a dosage of 25 mg/day.
  • Day 8: stop administration of trazodone and continue administration of amitriptyline in a dosage of 50 mg/day.
  • Start low, go slow.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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