Difference between revisions of "Venlafaxine-agomelatine"

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| from = venlafaxine  
 
| from = venlafaxine  
 
| to = agomelatine  
 
| to = agomelatine  
 
| stop =  
 
| stop =  
{{downVenla}}
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{{TCAdecrease25p3d}}
| start =  
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| start = {{StartAgomelatine|8}}
* '''Day 7:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.
 
* '''Day 15:''' continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
 
 
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Latest revision as of 12:09, 4 August 2023

Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from venlafaxine to agomelatine.[1] [2] [3]

Nietinrijdenbord.png Stop venlafaxine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start agomelatine
  • Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[4]
  • If necessary, increase dosage of agomelatine to 50 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. CBG meb, accessed august 2023,SmPC Valdoxan
  4. McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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