Difference between revisions of "Venlafaxine-hypericum"

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Revision as of 16:01, 2 November 2015

Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort

Switch medication from venlafaxine to hypericum.

Nietinrijdenbord.png Stop venlafaxine
  • Day 1-14: gradually reduce dosage of venlafaxine to a maximum of 37,5 mg or 75 mg (slow release)/ day.
  • Day 15: stop administration of venlafaxine
Eenrichtingbord.png Start hypericum
  • Day 15-21: a wash-out period of one week is necessary.
  • Day 22: start administration of hypericum.
Letopbord.png Cave
  • Occurrence of the serotonin syndrome is possible without wash-out period.
Infobord.png More information
  • Hypericum induces enzymes of the CYP P-450 type and P-gp type.
  • Hypericum might have MAO-inhibiting and/or COMT-inhibiting properties.
  • Many studies reported that hypericin is the main source of pharmacological effects of hypericum. However the IC50 of hypericin to inhibit MAO A and MAO B is 100- to 1000-fold higher than accessible Cmax values of hypericin after oral administration of hypericum.[1]
  • The T1/2 of hypericum is 19 - 37 hour.[2]
  • This switch is currently being reviewed.
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