Venlafaxine-mirtazapine

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Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine
Mirtazapine
Type Antidepressant
Group other
links
Medscape Mirtazapine
PubChem 4205
PubMed Mirtazapine
Kompas (Dutch) Mirtazapine
Wikipedia Mirtazapine

Switch medication from venlafaxine to mirtazapine.[1] [2]

Nietinrijdenbord.png Stop venlafaxine
  • Before day 1: gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
  • Day 1: reduce a dosage of 75 mg/day to 37,5 mg/day.
  • Day 8: stop administration of venlafaxine.
Eenrichtingbord.png Start mirtazapine
  • Day 1: simultaneously start administration of mirtazapine in a dosage of 15 mg/day.
  • Day 8: stop administration of venlafaxine and continue administration of mirtazapine only in a dosage of 30 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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