Vortioxetine-duloxetine

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Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from vortioxetine to duloxetine.

Nietinrijdenbord.png Stop vortioxetine
  • Day 1: reduce dosage of vortioxetine to 5 mg/day.
  • Day 8: stop administration of vortioxetine.
Eenrichtingbord.png Start duloxetine
  • Day 8-14: a wash-out period of 1 week is necessary.
  • Day 15: start administration of duloxetine in a dosage of 30 mg/day.
  • Day 22: bloodlevel vortioxetine is now zero, so you can increase faster. [1] [2]
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Duloxetine is a inhibitor of CYP2D6, which metabolizes vortioxetine.[3]
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