Difference between revisions of "Mirtazapine-doxepine"
From Psychiatrienet
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* '''Day 1:''' simultaneously start administration of doxepin in a dosage of 25 mg/day. | * '''Day 1:''' simultaneously start administration of doxepin in a dosage of 25 mg/day. | ||
* '''Day 8:''' stop administration of mirtazapine and continue administration of doxepin. If necessary, increase dosage of doxepin. | * '''Day 8:''' stop administration of mirtazapine and continue administration of doxepin. If necessary, increase dosage of doxepin. | ||
| − | * "Start low, go slow" is not required, but caution is necessary.}} | + | * "Start low, go slow" is not required, but caution is necessary. |
| + | | info = | ||
| + | {{review}} | ||
| + | }} | ||
Revision as of 14:16, 7 October 2015
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Switch medication from mirtazapine to doxepin.[2] [3]
Stop mirtazapine - Before day 1: gradually reduce dosage of mirtazapine to a maximum of 30 mg/ day.
- Day 1: reduce a dosage of 30 mg/day to 15 mg/day.
Start doxepinNo wash-out period is needed.
- Day 1: simultaneously start administration of doxepin in a dosage of 25 mg/day.
- Day 8: stop administration of mirtazapine and continue administration of doxepin. If necessary, increase dosage of doxepin.
- "Start low, go slow" is not required, but caution is necessary.
More information- This switch is currently being reviewed.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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