Difference between revisions of "Imipramine-mianserine"

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| to = mianserine  
 
| to = mianserine  
 
| stop =  
 
| stop =  
* '''Before day 0:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
+
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.
 
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
 
* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.
 
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.
 
* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.

Latest revision as of 12:56, 17 November 2009

Imipramine
Type Antidepressant
Group TCA
links
Medscape Imipramine
PubChem 3696
PubMed Imipramine
Kompas (Dutch) Imipramine
Wikipedia Imipramine
Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine

Switch medication from imipramine to mianserine.[1] [2]

Nietinrijdenbord.png Stop imipramine
  • Before day 1: gradually reduce dosage of imipramine to a maximum of 75 mg/day.
  • Day 1: reduce dosage of imipramine to 50 mg/day.
  • Day 3: reduce dosage of imipramine to 25 mg/day.
Eenrichtingbord.png Start mianserine
  • Day 1: simultaneously start administration of mianserine in a low dosage of 30 mg/day.
  • Day 8: stop administration of imipramine and continue administration of mianserine.
  • If necessary, increase dosage of mianserine.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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