Difference between revisions of "Citalopram-clomipramine"

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| to = clomipramine
 
| to = clomipramine
 
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* '''Day 0:''' gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of citalopram/escitalopram to a maximum of 10 mg/day resp. 5 mg/day.
 
* '''Day 8:''' stop administration of citalopram/escitalopram.
 
 
| start =  
 
| start =  
* '''Day 8:''' no wash-out period is needed. Start administration of clomipramine in a low dosage of 25-50 mg/day.
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{{TCAincrease25p3d}}
* Start low, go slow!
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| info =
| info =  
 
* The same applies to [[escitalopram]].
 
 
* {{theorSS}}
 
* {{theorSS}}
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{{TCAplasmalevelmonitoring}}
 
}}
 
}}

Latest revision as of 14:00, 30 June 2023

Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from citalopram to clomipramine.[1] [2]

Nietinrijdenbord.png Stop citalopram
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start clomipramine
  • Day 1: Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. (dutch) monografie.org tricyclische-antidepressiva
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