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Difference between revisions of "Combining-Lithium-Risperidone"

 
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{{Drugcombi
 
{{Drugcombi
| base = Lithium
+
| base = lithium
| add = Risperidone
+
| add = risperidone
 
| info =  
 
| info =  
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
+
* This combination may have additive side effects<ref name="freeman">{{Pubmed|9433333|Freeman et al. Mood stabilizer Combinations: A Review of Safety and Efficacy. Am J Psychiatry 1998;155:12-21}}</ref>.
* Risperidone is principally metabolized by CYP2D6 to an active metabolite.
+
 
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
 
 
| start =  
 
| start =  
 
* Start risperidone according to the general dosing advice.
 
* Start risperidone according to the general dosing advice.

Latest revision as of 11:50, 23 April 2010

Lithium
Type moodstabilizer
Group other
links
ATC-code N05AN01
Medscape Lithium
PubChem 11125
PubMed Lithium
Drugs.com lithium
Kompas (Dutch) Lithium
Wikipedia Lithium
Risperidone
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AX08
Medscape Risperidone
PubChem 5073
PubMed Risperidone
Drugs.com risperidone
Kompas (Dutch) Risperidone
Wikipedia Risperidone

Adding risperidone to lithium.

Infobord.png General information
  • Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
  • Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
  • This combination may have additive side effects[5].
Eenrichtingbord.png Start risperidone
  • Start risperidone according to the general dosing advice.
Letopbord.png Cave
  • The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.


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