Difference between revisions of "Clomipramine-vortioxetine"

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| to = vortioxetine  
 
| to = vortioxetine  
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of clomipramine to 25 mg/day.
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| start = {{StartAntidepressant}}
* '''Day 3:''' reduce dosage of clomipramine to 10 mg/day.
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| info =
* '''Day 8:''' stop administration of clomipramine.
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* Safe target dose vortioxetine = 10 mg
| start =  
 
* A wash-out period is not necessary.
 
* Start administration of vortioxetine the next day in a dosage of 10 mg/day.
 
| info =
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
 
}}
 
}}

Latest revision as of 11:10, 30 June 2023

Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
Vortioxetine
Type Antidepressant
Group SMS
links
Medscape Vortioxetine
PubChem 9966051
PubMed Vortioxetine
Kompas (Dutch) Vortioxetine
Wikipedia Vortioxetine

Switch medication from clomipramine to vortioxetine.[1] [2]

Nietinrijdenbord.png Stop clomipramine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start vortioxetine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose vortioxetine = 10 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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