Difference between revisions of "Bupropion-paroxetine"

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| to = paroxetine
 
| to = paroxetine
 
| stop =  
 
| stop =  
{{StopBupropion1}}
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{{StopBupropion}}
 
| start =  
 
| start =  
* ''' Day 2: ''' Start paroxetine in normal dosage of 20 mg/day.
+
* '''Day 1:''' start paroxetine the next day in low dosage of 10 mg/day.
* ''' After 3 weeks:''' If necessary increase dosage gradually to 30-50 mg/day.
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* '''Day 8:''' If necessary, gradually increase dosage
| info =
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| info =  
* No wash-out period is needed.
 
* Bupropion slows the metabolism of paroxetine by CYP2D6.
 
* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
 
* {{2D6NRI}}
 
 
}}
 
}}

Latest revision as of 11:31, 4 August 2023

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from bupropion to paroxetine.[1] [2]

Nietinrijdenbord.png Stop bupropion
  • Day 1: Stop bupropion.
  • bupropion can be stopped abruptly for every dosage.[3]
Eenrichtingbord.png Start paroxetine
  • Day 1: start paroxetine the next day in low dosage of 10 mg/day.
  • Day 8: If necessary, gradually increase dosage


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Multidisciplinair document Afbouwen Overige Antidepressiva 2023
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