Difference between revisions of "Mianserine-fluoxetine"

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| to = fluoxetine
 
| to = fluoxetine
 
| stop =  
 
| stop =  
* '''Day 0:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
+
* '''Before day 1:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
 
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day.
 
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day.
 
| start =   
 
| start =   
 
* '''Day 1:''' simultaneously start fluoxetine in a normal dosage of 20 mg/day.
 
* '''Day 1:''' simultaneously start fluoxetine in a normal dosage of 20 mg/day.
* '''Day 8:''' stop administration of mianserine and only continue administration of fluoxetine only.  
+
* '''Day 8:''' stop administration of mianserine and only continue administration of fluoxetine.  
* If necessary, increase the dosage of fluoxetine. }}
+
* If necessary, increase the dosage of fluoxetine.  
 +
| info =
 +
* Caution with this switch is necessary, because fluoxetine slows the metabolism of mianserine via CYP2D6.
 +
}}

Latest revision as of 15:09, 17 November 2009

Mianserine
Type Antidepressant
Group other
links
PubChem 4184
PubMed Mianserine
Kompas (Dutch) Mianserine
Wikipedia Mianserine
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from mianserine to fluoxetine.[1] [2]

Nietinrijdenbord.png Stop mianserine
  • Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
  • Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
Eenrichtingbord.png Start fluoxetine
  • Day 1: simultaneously start fluoxetine in a normal dosage of 20 mg/day.
  • Day 8: stop administration of mianserine and only continue administration of fluoxetine.
  • If necessary, increase the dosage of fluoxetine.
Infobord.png More information
  • Caution with this switch is necessary, because fluoxetine slows the metabolism of mianserine via CYP2D6.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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