Difference between revisions of "Bupropion-paroxetine"

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* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
 
* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
 
* {{2D6NRI}}
 
* {{2D6NRI}}
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Revision as of 13:57, 7 October 2015

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine

Switch medication from bupropion to paroxetine.[1] [2]

Nietinrijdenbord.png Stop bupropion
  • Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
  • When a dosage of 150 mg/day is reached, stop administration.
Eenrichtingbord.png Start paroxetine
  • No wash-out period is needed.
  • Start paroxetine the next day in normal dosage of 20 mg/day.
Infobord.png More information
  • Bupropion slows the metabolism of paroxetine by CYP2D6.
  • Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
  • The interaction by CYP2D6-inhibition is not relevant because of low dosages during the switch.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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