Difference between revisions of "Fluvoxamine-doxepine"
From Psychiatrienet
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* '''Day 1:''' simultaneously start administration of doxepin in a low dosage of 25 mg/day. | * '''Day 1:''' simultaneously start administration of doxepin in a low dosage of 25 mg/day. | ||
* '''Day 8:''' stop administration of fluvoxamine and continue administration of doxepin only. If necessary, increase dosage of doxepin. | * '''Day 8:''' stop administration of fluvoxamine and continue administration of doxepin only. If necessary, increase dosage of doxepin. |
Revision as of 14:03, 28 October 2015
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Switch medication from fluvoxamine to doxepin.[2] [3]
- Before day 1: gradually reduce dosage of fluvoxamine to a maximum of 50 mg/day, when this dosage is > 50 mg/day.
- Day 1: reduce dosage of fluvoxamine further to 25 mg/day.
- Day 8: stop administration of fluvoxamine.
- Day 1: simultaneously start administration of doxepin in a low dosage of 25 mg/day.
- Day 8: stop administration of fluvoxamine and continue administration of doxepin only. If necessary, increase dosage of doxepin.
- Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize doxepin.
- "Start low, go slow" is not required, but caution is necessary.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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