Difference between revisions of "Sertraline-citalopram"
From Psychiatrienet
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| − | + | {{Drugswitch | |
| + | | from = sertraline | ||
| + | | to = nortriptyline | ||
| + | | stop = | ||
| + | * '''Day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day. | ||
| + | * '''Day 1:''' reduce dosage of sertraline to a maximum of 25 mg/day. | ||
| + | | start = | ||
| + | Caution is necessary. | ||
| + | * '''Day 1:''' simultaneously start administration of nortriptyline in a low dosage of 25 mg/day. | ||
| + | * '''Day 8:''' stop administration of sertraline and only continue administration of nortriptyline in a dosage of 50 mg/day. | ||
| + | * "Start low, go slow" is not required, but caution is necessary. | ||
| + | | info = | ||
| + | * Sertraline dose-dependently slows the metabolism of amitriptyline via CYP2D6. }} | ||
Revision as of 21:05, 3 May 2009
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Switch medication from sertraline to nortriptyline.[1] [2]
Stop sertraline - Day 0: gradually reduce dosage of sertraline to a maximum of 50 mg/day when this dosage is > 50 mg/day.
- Day 1: reduce dosage of sertraline to a maximum of 25 mg/day.
Start nortriptylineCaution is necessary.
- Day 1: simultaneously start administration of nortriptyline in a low dosage of 25 mg/day.
- Day 8: stop administration of sertraline and only continue administration of nortriptyline in a dosage of 50 mg/day.
- "Start low, go slow" is not required, but caution is necessary.
More information- Sertraline dose-dependently slows the metabolism of amitriptyline via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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