Difference between revisions of "Mirtazapine-moclobemide"
From Psychiatrienet
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* '''Day 8-14:''' A wash-out period of one week is necessary. | * '''Day 8-14:''' A wash-out period of one week is necessary. | ||
* '''Day 15:''' Start administration of moclobemide 150 mg/day | * '''Day 15:''' Start administration of moclobemide 150 mg/day | ||
| − | * '' Day 23: ''' Increase moclobemide dosage to 300 mg/day | + | * ''' Day 23: ''' Increase moclobemide dosage to 300 mg/day |
| info = | | info = | ||
* Occurrence of serotonin syndrome is not very likely. For safety reasons a wash-out period (of one week) is considered. | * Occurrence of serotonin syndrome is not very likely. For safety reasons a wash-out period (of one week) is considered. | ||
}} | }} | ||
Revision as of 13:47, 7 October 2015
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Switch medication from mirtazapine to moclobemide.[1] [2]
Stop mirtazapine - Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
Start moclobemide- Day 8-14: A wash-out period of one week is necessary.
- Day 15: Start administration of moclobemide 150 mg/day
- Day 23: Increase moclobemide dosage to 300 mg/day
More information- Occurrence of serotonin syndrome is not very likely. For safety reasons a wash-out period (of one week) is considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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