Difference between revisions of "Mirtazapine-doxepine"
From Psychiatrienet
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No wash-out period is needed. | No wash-out period is needed. | ||
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| − | + | * Start administration of doxepin in a dosage of 25 mg/day. | |
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* "Start low, go slow" is not required, but caution is necessary. | * "Start low, go slow" is not required, but caution is necessary. | ||
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Revision as of 10:41, 14 October 2015
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Switch medication from mirtazapine to doxepin.[2] [3]
Stop mirtazapine - Before day 1: Gradually reduce dosage of mirtazapine to a maximum of 30 mg/day, when this dosage is > 30 mg/day.
- Day 1: Reduce dosage of mirtazapine to 15 mg/day.
- Day 8: Stop administration of mirtazapine.
Start doxepinNo wash-out period is needed.
- Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
- Start administration of doxepin in a dosage of 25 mg/day.
More information- "Start low, go slow" is not required, but caution is necessary.
- ↑ 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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