Difference between revisions of "Escitalopram-fluoxetine"

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| from = escitalopram
 
| from = escitalopram
 
| to = fluoxetine
 
| to = fluoxetine
| stop = {{StopEscitalopram}}
+
| stop = {{StopSSRI,SNRI}}
| start =  
+
| start = {{StartAntidepressant}}
* No wash-out period is needed.
+
| info =
* '''Day 9:''' start fluoxetine in normal dosage of 20 mg/day.
+
* Safe target dose fluoxetine = 20 mg
| info =
+
* {{Possiblestartstop}}
 
* {{theorSS}}
 
* {{theorSS}}
* Fluoxetine slows the metabolism of escitalopram by inhibition of CYP2C19, CYP2D6 and CYP3A4
 
 
}}
 
}}

Latest revision as of 16:14, 24 February 2023

Escitalopram
Type Antidepressant
Group SSRI
links
Medscape Escitalopram
PubChem 10832572
PubMed Escitalopram
Kompas (Dutch) Escitalopram
Wikipedia Escitalopram
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from escitalopram to fluoxetine.[1] [2]

Nietinrijdenbord.png Stop escitalopram
  • Day 1: Decrease dose to 50%
  • Day 8: Stop
Eenrichtingbord.png Start fluoxetine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose fluoxetine = 20 mg
  • A start stop switch is possible, although withdrawal symptoms and/or side effects are more likely
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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