Difference between revisions of "Paroxetine-agomelatine"
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* An extra reduction week to paroxetine 2,5 mg/day is sometimes necessary. | * An extra reduction week to paroxetine 2,5 mg/day is sometimes necessary. |
Revision as of 12:00, 4 August 2023
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Switch medication from paroxetine to agomelatine.[1] [2]
- Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
- Day 0: dosage of paroxetine is 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: reduce dosage of paroxetine to 5 mg/day.
- Day 15: stop administration of paroxetine.
- Day 1: simultaneously start administration of agomelatine in a dosage of 25 mg/day.[3]
- If necessary, increase dosage of agomelatine to 50 mg/day.
- An extra reduction week to paroxetine 2,5 mg/day is sometimes necessary.
- Low doses of paroxetine can be given by a paroxetine-solution.
- The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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