Difference between revisions of "Trazodone-mirtazapine"
From Psychiatrienet
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* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day. | * '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day. | ||
− | * '''Day 1:''' reduce dosage of trazodone to 75 mg/day. | + | * '''Day 1:''' reduce dosage of trazodone to 75-100 mg/day. |
* '''Day 8:''' stop administration of trazodone. | * '''Day 8:''' stop administration of trazodone. | ||
| start = | | start = | ||
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* '''Day 8:''' start administration of mirtazapine in a normal dosage of 15 mg/day. | * '''Day 8:''' start administration of mirtazapine in a normal dosage of 15 mg/day. | ||
* '''Day 15:''' increase dosage of mirtazapine to 30 mg/day. | * '''Day 15:''' increase dosage of mirtazapine to 30 mg/day. | ||
− | }} | + | | info = |
+ | * The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given. }} |
Revision as of 12:34, 10 July 2009
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Switch medication from trazodone to mirtazapine.[1] [2]
- Before day 0: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 75-100 mg/day.
- Day 8: stop administration of trazodone.
- A wash-out period is not necessary.
- Day 8: start administration of mirtazapine in a normal dosage of 15 mg/day.
- Day 15: increase dosage of mirtazapine to 30 mg/day.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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