Difference between revisions of "Dosulepine-fluoxetine"
From Psychiatrienet
(Created page with '{{Drugswitch | from = dosulepine | to = fluoxetine | stop = * '''Before day 0:''' gradually reduce dosage of dosulepine to a maximum of 75 mg/day. * '''Day 1:''' reduce dosag...') |
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* '''Day 1:''' reduce dosage of dosulepine to 50 mg/day. | * '''Day 1:''' reduce dosage of dosulepine to 50 mg/day. | ||
* '''Day 3:''' reduce dosage of dosulepine to 25 mg/day. | * '''Day 3:''' reduce dosage of dosulepine to 25 mg/day. | ||
| + | * '''Day 7:''' stop dosulepine | ||
| start = | | start = | ||
| − | * '''Day | + | * '''Day 8:''' start administration of fluoxetine in a normal dosage of 20 mg/day. |
| − | |||
| info = | | info = | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes dosulepine. }} | * Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes dosulepine. }} | ||
Revision as of 10:21, 13 July 2009
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Switch medication from dosulepine to fluoxetine.[1] [2]
Stop dosulepine - Before day 0: gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
- Day 1: reduce dosage of dosulepine to 50 mg/day.
- Day 3: reduce dosage of dosulepine to 25 mg/day.
- Day 7: stop dosulepine
Start fluoxetine- Day 8: start administration of fluoxetine in a normal dosage of 20 mg/day.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes dosulepine.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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