Difference between revisions of "Amitriptyline-imipramine"
From Psychiatrienet
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Revision as of 14:40, 3 February 2010
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Switch medication from amitriptyline to imipramine.[1] [2]
- Gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/day.
- When a dosage of 50-100 mg/day is reached, stop administration.
- No wash-out period is needed.
- Start administration of imipramine the next day in a normal dosage of 50-100 mg/day.
- Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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