Difference between revisions of "Olanzapine-Zuclopenthixol MA"

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Latest revision as of 16:17, 15 February 2010

Olanzapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH03
Medscape Olanzapine
EMEA zyprexa
PubChem 4585
PubMed Olanzapine
Drugs.com olanzapine
Kompas (Dutch) Olanzapine
Wikipedia Olanzapine
Zuclopenthixol
Medium long acting
Type Antipsychotic
Group Thioxanthenes
links
PubChem 5311507
PubMed Zuclopenthixol
Kompas (Dutch) Zuclopenthixol
Wikipedia Zuclopenthixol

Switch medication from Olanzapine to Zuclopenthixol_MA.[4] [5]

Nietinrijdenbord.png Stop Olanzapine
  • Stop or reduce drug, depending on symptomatology and (expected) adverse reactions.
  • The effects of both drugs will be superimposed for several days.
Eenrichtingbord.png Start Zuclopenthixol_MA
  • Day 1: Start drug according general dosing advice.
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[6]
  • Zuclopenthixol_MA = Zuclopenthixol acetate [7]
  1. 1.0 1.1 1.2 1.3 KNMP; Informatorium Medicamentorum 2023; Monografie "olanzapine" (Dutch)
  2. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
  4. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  5. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  6. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
  7. SPC Zuclopenthixol acetate
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