Difference between revisions of "Paroxetine-clomipramine"

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* '''Day 28:''' if necessary, increase dosage of clomipramine.
 
* '''Day 28:''' if necessary, increase dosage of clomipramine.
 
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| info =  
* Paroxetine slows the metabolism of clomipramine via CYP2D6. }}
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* Paroxetine slows the metabolism of clomipramine via CYP2D6.
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{{review}}
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Revision as of 15:46, 21 October 2015

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine

Switch medication from paroxetine to clomipramine.[1] [2]

Nietinrijdenbord.png Stop paroxetine
  • Before day 1: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
  • Day 8: stop dosage of paroxetine.
Eenrichtingbord.png Start clomipramine

Caution is necessary.

  • Day 8: start administration of clomipramine in a low dosage of 25-50 mg/day.
  • Day 15: increase dosage of clomipramine to 50-100 mg/day.
  • Day 28: if necessary, increase dosage of clomipramine.
Infobord.png More information
  • Paroxetine slows the metabolism of clomipramine via CYP2D6.
  • This switch is currently being reviewed.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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