Difference between revisions of "Fluoxetine-doxepine"

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| to = doxepin
 
| to = doxepin
 
| stop =  
 
| stop =  
* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
+
{{stopFluoxetine1}}
* When a dosage of 20 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
 
Caution is necessary for at least four weeks.
 
Caution is necessary for at least four weeks.
* '''Day 1:''' start administration of doxepin in a low dosage of 25 mg/day.
+
* '''Day 2:''' start administration of doxepin in a low dosage of 25 mg/day.
* '''Day 14:''' increase dosage of doxepin to 50 mg/day.
+
* '''Day 15:''' increase dosage of doxepin to 50 mg/day.
* '''Day 28:''' increase dosage of doxepin to 75 mg/day.
+
* '''Day 29:''' increase dosage of doxepin to 75 mg/day.
 
| info =   
 
| info =   
 
* Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6.  
 
* Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6.  
* Norfluoxetine has a halflife of at least 1 week: it takes therefore 1 month for elemination.
+
{{longt1/2fluvox}}
 
* Start low, go slow for doxepin.
 
* Start low, go slow for doxepin.
{{review}}}}
 

Revision as of 13:43, 28 October 2015

{{Drugswitch | from = fluoxetine | to = doxepin | stop =

  • Before day 1: reduce dosage of fluoxetine with about 20 mg per week.
  • Day 1: when a dosage of 20 mg/day is reached, stop fluoxetine.

| start = Caution is necessary for at least four weeks.

  • Day 2: start administration of doxepin in a low dosage of 25 mg/day.
  • Day 15: increase dosage of doxepin to 50 mg/day.
  • Day 29: increase dosage of doxepin to 75 mg/day.

| info =

  • Fluoxetine and norfluoxetine slow the metabolism of doxepin via CYP2D6.
  • Fluoxetine and its metababolite desmethyl-fluoxetine have a very long elimination time of about 1 week; phasing out fluoxetine is therefore not necessary.
  • Start low, go slow for doxepin.