Difference between revisions of "Maprotiline-escitalopram"

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| to = escitalopram  
 
| to = escitalopram  
 
| stop =  
 
| stop =  
{{stopMaprotiline}}
+
{{TCAdecrease25p3d}}
| start =  
+
| start = {{StartAntidepressant}}
* '''Day 7:''' simultaneously start administration of escitalopram in a normal dosage of 10 mg/day.
+
| info =
| info =  
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* Safe target dose escitalopram = 10 mg
* Escitalopram is a weak inhibitor of CYP2D6, which metabolizes maprotiline. 
 
 
}}
 
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Latest revision as of 11:46, 30 June 2023

Maprotiline
Type Antidepressant
Group NRI
links
Medscape Maprotiline
PubChem 4011
PubMed Maprotiline
Kompas (Dutch) Maprotiline
Wikipedia Maprotiline
Escitalopram
Type Antidepressant
Group SSRI
links
Medscape Escitalopram
PubChem 10832572
PubMed Escitalopram
Kompas (Dutch) Escitalopram
Wikipedia Escitalopram

Switch medication from maprotiline to escitalopram.[1] [2]

Nietinrijdenbord.png Stop maprotiline
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start escitalopram
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose escitalopram = 10 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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