Agomelatine-hypericum

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Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine
Hypericum
Type Antidepressant
Group other
links
EMEA 10130408en
PubMed Hypericum
Kompas (Dutch) hypericum extract
Wikipedia St John's wort

Switch medication from agomelatine to hypericum.[1] [2]

Nietinrijdenbord.png Stop agomelatine
  • Agomelatonine can be stopped abruptly for every dosage.
Eenrichtingbord.png Start hypericum
  • No wash-out period is necessary.
  • Start administration of hypericum the next day in a dosage of 300 mg three times a day (900 mg/day).
Infobord.png More information
  • Hypericum induces the metabolism of agomelatine via CYP1A2.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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