Combining-Lithium-Risperidone
From Psychiatrienet
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Adding Risperidone to Lithium.
General information- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite 9-OH-risperidone (paliperidone).
- Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
- Risperidone is principally metabolized by CYP2D6 to an active metabolite.
- This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
Start Risperidone- Start risperidone according to the general dosing advice.
- ↑ Farmacotherapeutisch Kompas - lithium (dutch)
- ↑ 2.0 2.1 KNMP; Informatorium Medicamentorum 2023; Monografie "risperidon" (Dutch)
- ↑ Woods SW; Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
- ↑ 4.0 4.1 The Lundbeck Institute; Psychotropics; Terminal Plasma Half-lives
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