Tranylcypromine-venlafaxine
From Psychiatrienet
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Switch medication from tranylcypromine to venlafaxine.[1] [2]
Stop tranylcypromine - Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
- When a dosage of 10 mg/day is reached, stop administration.
Start venlafaxine- Day 1-14: a wash-out period of two weeks is necessary.
- Day 15: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
Cave- Occurrence of the serotonin syndrome is possible without wash-out period.
More information- The wash-out period is necessary for the MAO enzymes to restore their function.
- This switch is currently being reviewed.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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