Citalopram-clomipramine
From Psychiatrienet
| ||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||
Switch medication from citalopram to clomipramine.[1] [2]
Stop citalopram - Day 0: gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
- Day 1: reduce dosage of citalopram/escitalopram to a maximum of 10 mg/day resp. 5 mg/day.
- Day 8: stop administration of citalopram/escitalopram.
Start clomipramine- Day 8: no wash-out period is needed. Start administration of clomipramine in a low dosage of 50-75 mg/day.
- Start low, go slow!
Cave- Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.
More information- The same applies to Escitalopram.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
