Aripiprazole-Paliperidone LA

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Ariprazole
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
EMEA abilify
PubChem 60975
PubMed Ariprazole
Kompas (Dutch) Ariprazole
Wikipedia Ariprazole
Paliperidone
long acting
Type Antipsychotic
Group Atypical AP
links
Medscape Paliperidone
PubChem 23724979
PubMed Paliperidone
Kompas (Dutch) Paliperidone
Wikipedia Paliperidone

Switch medication from Aripiprazole to Paliperidone_LA.[1] [2]

Nietinrijdenbord.png Stop Aripiprazole
  • Week 1-6: Continue drug at usual dose
  • Week 7: Stop drug
Eenrichtingbord.png Start Paliperidone_LA
  • Day 1: Start depot according general dosing advice (Dotted line in graph)

Paliperidone palmitate is since spring 2011 approved by EMEA: therefore this switch is under construction.

Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[3]
  • Alternatively, first switch to oral form and then switch to depot to manage possible (adverse) reactions. With a direct switch to a depot it is advisable to administer a low testdose in order to exclude adverse reactions.
    StopArip7WeeksStartDepot.jpg
Nietinrijdenbord.png — Aripiprazole
Eenrichtingbord.png — Paliperidone_LA


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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