Combining-Carbamazepine-Quetiapine

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Carbamazepine
Type moodstabilizer
Group anticonvulsant
links
ATC-code N03AF01
Medscape Carbamazepine
PubChem 2554
PubMed Carbamazepine
Drugs.com carbamazepine
Kompas (Dutch) Carbamazepine
Wikipedia Carbamazepine
Quetiapine
Type antipsychotic
Group atypical AP
Other use moodstabilizer
links
ATC-code N05AH04
Medscape Quetiapine
PubChem 5002
PubMed Quetiapine
Drugs.com quetiapine-fumarate
Kompas (Dutch) Quetiapine
Wikipedia Quetiapine

Adding Quetiapine to Carbamazepine.

Infobord.png General information
  • Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
  • Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
  • Quetiapine is principally metabolized by CYP3A4 to active and inactive metabolites.
Eenrichtingbord.png Start Quetiapine
  • Carbamazepine can reduce quetiapine serum concentration, possible below therapeutic range. [8]
  • Add quetiapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. [9] [10]



  1. WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
  2. Farmacotherapeutisch Kompas; Toxicologie (dutch)
  3. Farmacotherapeutisch Kompas - carbamazepine (dutch)
  4. 4.0 4.1 4.2 4.3 KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch) Cite error: Invalid <ref> tag; name "informatorium" defined multiple times with different content
  5. NVZA; Toxicology.org; Monografie 73 (dutch)
  6. Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics J Clin Psychiatry 2003;64:663-667
  7. Drugs.com quetiapine-fumarate
  8. Hasselstrom and Linnet, Quetiapine serum concentrations in psychiatric patients: the influence of comedication. Ther Drug Monit 2004;26:486-91
  9. Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
  10. Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
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