Difference between revisions of "Agomelatine-doxepine"

From Psychiatrienet
Jump to: navigation, search
Line 2: Line 2:
 
| from = agomelatine  
 
| from = agomelatine  
 
| to = doxepin  
 
| to = doxepin  
| stop =  
+
| stop = {{StopAgomelatine}}
* Agomelatine can be stopped abruptly for every dosage.
 
 
| start =  
 
| start =  
 
* A wash-out period is not necessary.
 
* A wash-out period is not necessary.
Line 9: Line 8:
 
* '''Day 2:''' increase dosage of doxepin to 50 mg/day.
 
* '''Day 2:''' increase dosage of doxepin to 50 mg/day.
 
* If necessary, increase dosage of doxepin with 25 mg every 2-3 days.  
 
* If necessary, increase dosage of doxepin with 25 mg every 2-3 days.  
<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
+
 
 
}}
 
}}

Revision as of 13:34, 5 March 2010

Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine
Doxepin
Type antidepressant
Group TCA
links
ATC-code N06AA12
Medscape Doxepin
PubChem 3158
PubMed Doxepin
Drugs.com doxepin
Kompas (Dutch) Doxepin
Wikipedia Doxepin

Switch medication from agomelatine to doxepin.[2] [3]

Nietinrijdenbord.png Stop agomelatine
  • Day 1: Stop agomelatine.
  • Agomelatine can be stopped abruptly for every dosage.[4]
Eenrichtingbord.png Start doxepin
  • A wash-out period is not necessary.
  • Day 1: start administration of doxepin the next day in a dosage of 25 mg/day.
  • Day 2: increase dosage of doxepin to 50 mg/day.
  • If necessary, increase dosage of doxepin with 25 mg every 2-3 days.


  1. 1.0 1.1 1.2 1.3 1.4 KNMP; Informatorium Medicamentorum 2023; Monografie "doxepine" (Dutch)
  2. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  3. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  4. McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.