Switch medication from amitriptyline to venlafaxine.
- Before day 1: gradually reduce dosage of amitriptyline to a maximum of 50-100 mg/ day, when this dosage is > 100 mg/day.
- Day 1-3: reduce dosage of amitriptyline to 50 mg/day.
- Day 4-7: reduce dosage of amitriptyline to 25 mg/day.
- Day 8: stop administration of amitriptyline..
- Day 9-15: a wash-out period of one week is necessary.
- Day 16: Start administration of venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.
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