Bupropion-duloxetine

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Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from bupropion to duloxetine.

Nietinrijdenbord.png Stop bupropion
  • Before day 1: gradually reduce dosage of bupropion to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
  • Day 1: reduce dosage of bupropion to 150 mg/day.
  • Day 8: stop administration of bupropion.
Eenrichtingbord.png Start duloxetine
  • Day 2: Start with normal dosage and increase with about 25% (up to 50%) every 3 days to target dose.
Infobord.png More information
  • No wash-out period is needed.
  • Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
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