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* Gradually reduce dosage of bupropion to a maximum of 150 mg/day.
* When a dosage of 150 mg/day is reached, stop administration.<ref> Kennedy et al, [http://www.ncbi.nlm.nih.gov/pubmed/11926715?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects.]. J Clin Psychiatry 2002 March;63(3):181-6.</ref>
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* '''Day 1-7:''' a wash-out period of at least one week is necessary.
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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
* Bupropion slows the metabolism of venlafaxine by CYP2D6.<ref> Kennedy et al, [http://www.ncbi.nlm.nih.gov/pubmed/11926715?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects.]. J Clin Psychiatry 2002 March;63(3):181-6.</ref>
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