Difference between revisions of "Bupropion-venlafaxine"

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* Gradually reduce dosage of bupropion to a maximum of 150 mg/day.
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* When a dosage of 150 mg/day is reached, stop administration.
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* '''Day 1-7:''' a wash-out period of at least one week is necessary.  
 
* '''Day 1-7:''' a wash-out period of at least one week is necessary.  
* '''Day 8:''' start venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day.  
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* '''Day 8:''' start venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day. Increase the dose with about 25% of the target dose every 3 days
 
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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.  
 
* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.  
* Bupropion slows the metabolism of venlafaxine by CYP2D6.<ref> Kennedy et al, [http://www.ncbi.nlm.nih.gov/pubmed/11926715?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Antipsychotic drugs and QT prolongation]. J Clin Psychiatry 2002 March;63(3):181-6.</ref>
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* Bupropion slows the metabolism of venlafaxine by CYP2D6.<ref> Kennedy et al, [http://www.ncbi.nlm.nih.gov/pubmed/11926715?ordinalpos=11&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: a preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects.]. J Clin Psychiatry 2002 March;63(3):181-6.</ref>
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Latest revision as of 12:42, 14 October 2015

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Venlafaxine
Type Antidepressant
Group SNRI
links
Medscape Venlafaxine
PubChem 5656
PubMed Venlafaxine
Kompas (Dutch) Venlafaxine
Wikipedia Venlafaxine

Switch medication from bupropion to venlafaxine.

Nietinrijdenbord.png Stop bupropion
  • Before day 1: gradually reduce dosage of bupropion to a maximum of 300 mg/day, when this dosage is > 300 mg/day.
  • Day 1: reduce dosage of bupropion to 150 mg/day.
  • Day 8: stop administration of bupropion.
Eenrichtingbord.png Start venlafaxine
  • Day 1-7: a wash-out period of at least one week is necessary.
  • Day 8: start venlafaxine in a normal dosage of 37,5 mg or 75 mg (slow release) /day. Increase the dose with about 25% of the target dose every 3 days
Infobord.png More information
  • By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur.
  • Bupropion slows the metabolism of venlafaxine by CYP2D6.[1]
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