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Chlorpromazine-Flupenthixol LA

Chlorpromazine
Type Antipsychotic
Group Phenothiazines
links
Medscape Chlorpromazine
PubChem 2726
PubMed Chlorpromazine
Kompas (Dutch) Chlorpromazine
Wikipedia Chlorpromazine
Flupenthixol
long acting
Type Antipsychotic
Group Thioxanthenes
links
Medscape Flupenthixol
PubChem 17012
PubMed Flupenthixol
Kompas (Dutch) Flupenthixol
Wikipedia Flupenthixol

Switch medication from Chlorpromazine to Flupenthixol_LA.

Nietinrijdenbord.png Stop Chlorpromazine
  • Week 1-3: approx. 75% of initial dose
  • Week 4-6: approx. 50% of initial dose
  • Week 7-9: approx. 25% of initial dose
  • Week 10: stop
Eenrichtingbord.png Start Flupenthixol_LA
  • Day 1: Start depot according general dosing advice (Dotted line in graph)
Infobord.png More information
  • During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
  • There is a possibility of QT interval prolongation.[1]
  • Alternatively, first switch to oral form and then switch to depot to manage possible (adverse) reactions. With a direct switch to a depot it is advisable to administer a low testdose in order to exclude adverse reactions.
    Stop10WeeksStartDepot.jpg
Nietinrijdenbord.png — Chlorpromazine
Eenrichtingbord.png — Flupenthixol_LA


  1. Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
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