Difference between revisions of "Citalopram-agomelatine"

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* '''Day 15:''' start administration of agomelatine in a dosage of 25 mg/day.
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* '''Day 16:''' start administration of agomelatine in a dosage of 25 mg/day.
* '''Day 22:''' if necessary, increase dosage of agomelatine to 50 mg/day.  
+
* '''Day 23:''' if necessary, increase dosage of agomelatine to 50 mg/day.  
 
<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
 
<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
  

Revision as of 13:27, 21 October 2015

Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram
Agomelatine
Type Antidepressant
Group other
links
ATC-code N06AX22
EMEA valdoxan
PubChem 82148
PubMed Agomelatine
Kompas (Dutch) Agomelatine
Wikipedia Agomelatine

Switch medication from citalopram to agomelatine.[1] [2]

Nietinrijdenbord.png Stop citalopram
  • Day 1: reduce dosage of citalopram to a maximum of 20 mg/day
  • Day 8: reduce dosage of citalopram to 10 mg/day
  • Day 15: stop citalopram
Eenrichtingbord.png Start agomelatine
  • Day 16: start administration of agomelatine in a dosage of 25 mg/day.
  • Day 23: if necessary, increase dosage of agomelatine to 50 mg/day.

[3]

Infobord.png More information
  • The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102
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