Citalopram-dosulepine

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Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from citalopram to dosulepine.[1] [2]

Nietinrijdenbord.png Stop citalopram
  • Before day 1: gradually reduce dosage of citalopram/escitalopram to a maximum of 20 mg/ day resp. 10 mg/day, when this dosage is respectively > 20 mg/day and > 10 mg/day.
  • Day 1: reduce dosage of citalopram/escitalopram to a maximum of 10 mg/ day resp. 5 mg/day.
  • Day 8: stop administration of citalopram/escitalopram
Eenrichtingbord.png Start dosulepine
  • Day 1: simultaneously start administration of dosulepine in a normal dosage of 50-75 mg/day.
  • Day 8: continue administration of dosulepine only.
Infobord.png More information
  • “Start low, go slow” for dosulepine is not required, but caution is necessary.
  • The same applies to escitalopram.
  • Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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