Difference between revisions of "Citalopram-tranylcypromine"

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| start =  
 
| start =  
* '''Day 15-22:''' a wash-out period of one week is necessary.
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* '''Day 15-29:''' a wash-out period of two weeks is safe even in liver malfunction and in the elderly.
* '''Day 23:''' Start administration of tranylcypromine in low dosage of 20 mg/day for one week.
+
* '''Day 30:''' Start administration of tranylcypromine in low dosage of 20 mg/day for one week.
* '''Day 31:''' after this week the dosage of tranylcypromine can be increased if necessary.  
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* '''Day 37:''' after this week the dosage of tranylcypromine can be increased if necessary.  
 
| caveat =  
 
| caveat =  
 
* Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.  
 
* Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.  
 
{{SSRI14d}}
 
{{SSRI14d}}
 
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Revision as of 10:04, 21 October 2015

Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram
Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine

Switch medication from citalopram to tranylcypromine.[1] [2]

Nietinrijdenbord.png Stop citalopram
  • Day 1: reduce dosage of citalopram to a maximum of 20 mg/day
  • Day 8: reduce dosage of citalopram to a maximum of 10 mg/day
  • Day 15: stop citalopram
Eenrichtingbord.png Start tranylcypromine
  • Day 15-29: a wash-out period of two weeks is safe even in liver malfunction and in the elderly.
  • Day 30: Start administration of tranylcypromine in low dosage of 20 mg/day for one week.
  • Day 37: after this week the dosage of tranylcypromine can be increased if necessary.
Letopbord.png Cave
  • Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.
  • The reduction of the SSRI doses in 7-14 days could cause emotional instability, headache and flu-like symptoms. One could extend this period.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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