Difference between revisions of "Clomipramine-dosulepine"

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| to = dosulepine
 
| to = dosulepine
 
| stop =  
 
| stop =  
* Gradually reduce dosage of clomipramine to a maximum of 75 mg/day.
+
{{downClomi}}
* When a dosage of 75 mg/day is reached, stop administration.
 
 
| start =  
 
| start =  
 
* No wash-out period is needed.  
 
* No wash-out period is needed.  
* Start administration of dosulepine the next day in a normal dosage of 50-75 mg/day.
+
* ''' Day 2: ''' start administration of dosulepine in a normal dosage of 50-75 mg/day.
 
| info =
 
| info =
 
* {{TCAantichol}}
 
* {{TCAantichol}}
{{review}}
 
 
}}
 
}}

Revision as of 12:07, 4 November 2015

Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from clomipramine to dosulepine.[1] [2]

Nietinrijdenbord.png Stop clomipramine
  • Before day 1: gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
  • Day 1: when a dosage of 75 mg/day is reached, stop administration.
Eenrichtingbord.png Start dosulepine
  • No wash-out period is needed.
  • Day 2: start administration of dosulepine in a normal dosage of 50-75 mg/day.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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