Difference between revisions of "Clomipramine-duloxetine"

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| to = duloxetine
 
| to = duloxetine
 
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| stop =  
* '''Before day 1:''' gradually reduce dosage of clomipramine to a maximum of 50 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1-7:''' reduce dosage of clomipramine to 25 mg/day.
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| start = {{StartAntidepressant}}
* '''Day 8:''' stop administration of clomipramine.
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| info =
| start =  
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* Safe target dose duloxetine = 60 mg
* '''Day 8-14:''' a wash-out period of one week is necessary.
 
* '''Day 15:''' start administration of duloxetine in a normal dosage of 60 mg/day.
 
| info =
 
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
 
* Duloxetine is an inhibitor of CYP2D6, which metabolizes clomipramine.
 
 
}}
 
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Latest revision as of 11:03, 30 June 2023

Clomipramine
Type Antidepressant
Group TCA
links
ATC-code N06AA04
Medscape Clomipramine
PubChem 2801
PubMed Clomipramine
Kompas (Dutch) Clomipramine
Wikipedia Clomipramine
Duloxetine
Type Antidepressant
Group SNRI
links
Medscape Duloxetine
PubChem 60835
PubMed Duloxetine
Kompas (Dutch) Duloxetine
Wikipedia Duloxetine

Switch medication from clomipramine to duloxetine.[1] [2]

Nietinrijdenbord.png Stop clomipramine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start duloxetine
  • Day 1: Start with 50% of the target dose
  • Day 8: Increase dose to 100% of the target dose
  • Day 9 and after: Gradually increase dose as necessary
Infobord.png More information
  • Safe target dose duloxetine = 60 mg
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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