Difference between revisions of "Clomipramine-tranylcypromine"
From Psychiatrienet
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* '''Day 8-14:''' a wash-out period of one week is necessary. | * '''Day 8-14:''' a wash-out period of one week is necessary. | ||
| − | * '''Day 15:''' start administration of tranylcypromine in a normal dosage of 20 mg/day.}} | + | * '''Day 15:''' start administration of tranylcypromine in a normal dosage of 20 mg/day. |
| + | | info = | ||
| + | * Caution with this switch is necessary, and a wash-out period in particular is important.}} | ||
Revision as of 09:06, 6 May 2009
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Switch medication from clomipramine to tranylcypromine.[1] [2]
Stop clomipramine - Day 0: gradually reduce dosage of clomipramine to a maximum of 75 mg/ day, when this dosage is > 75 mg/day.
- Day 1-3: reduce dosage of clomipramine to 50 mg/day.
- Day 4-7: reduce dosage of clomipramine to 25 mg/day.
- Day 8: stop administration of clomipramine.
Start tranylcypromine- Day 8-14: a wash-out period of one week is necessary.
- Day 15: start administration of tranylcypromine in a normal dosage of 20 mg/day.
More information- Caution with this switch is necessary, and a wash-out period in particular is important.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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